Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Maria A Neginskaya; Evgeny V Pavlov

doi:10.1007/978-3-031-01237-2_2

Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology

Prog Mol Subcell Biol. 2022:61:15-26. doi: 10.1007/978-3-031-01237-2_2.

Authors

Maria A Neginskaya¹, Evgeny V Pavlov²

Affiliations

¹ Department of Molecular Pathobiology, New York University, New York, NY, USA.
² Department of Molecular Pathobiology, New York University, New York, NY, USA. ep37@nyu.edu.

PMID: 35697935
DOI: 10.1007/978-3-031-01237-2_2

Abstract

In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

Keywords: ATP; Calcium; Mitochondrial function; Oxidative phosphorylation; Permeability transition pore; PolyP hydrolyzing enzyme; Polyhydroxybutyrate; Polyphosphate kinase.

MeSH terms

Energy Metabolism / genetics
Mitochondria / genetics
Mitochondrial Membrane Transport Proteins / metabolism
Mitochondrial Permeability Transition Pore*
Polyphosphates* / metabolism

Substances

Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
Polyphosphates