Understanding COVID-19 Situation in Nepal and Implications for SARS-CoV-2 Transmission and Management

Prabin Dawadi; Gopiram Syangtan; Bhupendra Lama; Sushil R Kanel; Dev Raj Joshi; Lok R Pokhrel; Rameshwar Adhikari; Hem R Joshi; Ioana Pavel

doi:10.1177/11786302221104348

Understanding COVID-19 Situation in Nepal and Implications for SARS-CoV-2 Transmission and Management

Environ Health Insights. 2022 Jun 7:16:11786302221104348. doi: 10.1177/11786302221104348. eCollection 2022.

Authors

Prabin Dawadi^{1

2}, Gopiram Syangtan^{2

3}, Bhupendra Lama², Sushil R Kanel⁴, Dev Raj Joshi², Lok R Pokhrel⁵, Rameshwar Adhikari⁶, Hem R Joshi⁷, Ioana Pavel⁸

Affiliations

¹ Biological Resources Unit, Nepal Academy of Science and Technology, Lalitpur, Bagmati, Nepal.
² Central Department of Microbiology, Tribhuvan University, Kathmandu, Bagmati, Nepal.
³ Shi-Gan International College of Science and Technology, Tribhuvan University, Kathmandu, Bagmati, Nepal.
⁴ Department of Chemistry, Wright State University, Dayton, OH, USA.
⁵ Department of Public Health, The Brody School of Medicine, East Carolina University, Greenville, NC, USA.
⁶ Research Center for Applied Science and Technology, Tribhuvan University, Kathmandu, Nepal.
⁷ Department of Mathematics, Xavier University, Cincinnati, OH, USA.
⁸ Department of Physical and Environmental Sciences, Texas A&M University at Corpus Christi, Corpus Christi, TX, USA.

Abstract

Background: The pandemic of Coronavirus Disease 2019 (COVID-19), one of the most infectious diseases in the modern history, is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and has had a profound health and economic toll, globally. This paper identifies the overall health status associated with COVID-19 pandemic in all 7 provinces of Nepal, a developing country in South Asia, analyzing data from January 2020 to February 2022. It focuses on the SARS-CoV-2 prevalence, transmission through wastewater and other routes, diagnostics, treatment options, and alternative medicines, thereby offering key perspectives for its management.

Materials and methods: Studies regarding coronavirus spanning the 2017 to 2022 period were searched on the web, Nepalese database, and Web of Science. Refined criteria included SARS-CoV-2 in wastewater of Nepal or worldwide. Demographic data (sex, age-group, and geographic location) were also obtained from websites and relevant reports of the Ministry of Health and Population (MOHP) of Nepal, ranging from January 2020 to February 2022. Moreover, trends concerning lockdown, business, and border activities in Nepal between February 2020 and October 2020 were evaluated. The viral dissemination pathways, diagnosis, and available treatment options, including the Ayurvedic medicine, were also examined.

Results: Aerosols generated during the hospital, industrial, recreational, and household activities were found to contribute to the propagation of SARS-CoV-2 into environmental wastewater, thereby putting the surrounding communities at risk of infection. When lockdown ended and businesses opened in October 2020, the number of active cases of COVID-19 increased exponentially. Bagmati Province had the highest number of cases (53.84%), while the remaining 6 provinces tallied 46.16%. Kathmandu district had the highest number of COVID-19 cases (138, 319 cases), while Manang district had the smallest number of infections (81 cases). The male population was found to be predominantly infected (58.7%). The most affected age groups were the 31 to 40 years old males (25.92%) and the 21 to 30 years old females (26.85%).

Conclusion: The pandemic impacted the public health and economic growth in our study duration. SARS-CoV-2 was prevalent in the wastewater of Nepal. The Terai districts and the megacities were mostly affected by SARS-CoV-2 infections. Working-age groups and males were identified as the highest risk groups. More investigations on the therapeutic and alternative cures are recommended. These findings may guide the researchers and professionals with handling the COVID-19 challenges in developing countries such as Nepal and better prepare for future pandemics.

Keywords: COVID-19; Nepal; SARS-CoV-2; pandemic; wastewater surveillance.