Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study

PeerJ. 2022 Jun 6:10:e13550. doi: 10.7717/peerj.13550. eCollection 2022.

Abstract

Aim: Previous studies have shown that the fibrinogen to albumin ratio (FAR) is closely related to the severity and prognosis of coronary atherosclerosis. In this study, we sought to evaluate the association between FAR and the degree of coronary artery calcification (CAC) in patients with chronic kidney disease (CKD).

Methods: In this retrospective study, 218 patients with CKD were stratified into low, medium and high FAR groups according to the tertiles of the FAR values. The CAC scores, clinical information and laboratory test results of the three FAR groups were compared. To explore the relationship between FAR and CAC we conducted binary logistic regression and correlation analyses.

Results: In the low FAR group, the CAC scores were significantly lower than those in the medium and high FAR groups (P < 0.001). There was a significant correlation between the FAR and CAC scores (r = 0.510, P < 0.001). The FAR was an independent predictor of CAC (OR = 1.106, 95% CI [1.004-1.218], P = 0.042).

Conclusion: In patients with CKD, the FAR can be considered as an effective predictor of CAC.

Keywords: Chronic kidney disease; Coronary artery calcification; Fibrinogen/albumin ratio.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins
  • Coronary Artery Disease* / complications
  • Fibrinogen
  • Humans
  • Renal Insufficiency, Chronic* / complications
  • Retrospective Studies
  • Vascular Calcification* / diagnostic imaging

Substances

  • Fibrinogen
  • Albumins

Grants and funding

This work was supported by grants from the Natural Science Foundation of Anhui Province (2008085MH244) and the Science Foundation of Anhui Medical University (2019xkj140). Refinement and implementation of the study were supported by The Second Affiliated Hospital of Anhui Medical University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.