3D Amide Proton Transfer Weighted Brain Tumor Imaging With Compressed SENSE: Effects of Different Acceleration Factors

Nan Zhang; Haonan Zhang; Bingbing Gao; Yanwei Miao; Ailian Liu; Qingwei Song; Liangjie Lin; Jiazheng Wang

doi:10.3389/fnins.2022.876587

3D Amide Proton Transfer Weighted Brain Tumor Imaging With Compressed SENSE: Effects of Different Acceleration Factors

Front Neurosci. 2022 May 26:16:876587. doi: 10.3389/fnins.2022.876587. eCollection 2022.

Authors

Nan Zhang^{1

2}, Haonan Zhang¹, Bingbing Gao¹, Yanwei Miao¹, Ailian Liu¹, Qingwei Song¹, Liangjie Lin³, Jiazheng Wang³

Affiliations

¹ Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
² Department of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.
³ MSC Clinical and Technical Solutions, Philips Healthcare, Beijing, China.

Abstract

Objectives: The aim of the current study was to evaluate the performance of compressed SENSE (CS) for 3D amide proton transfer weighted (APTw) brain tumor imaging with different acceleration factors (AFs), and the results were compared with those of conventional SENSE.

Methods: Approximately 51 patients with brain tumor (22 males, 49.95 ± 10.52 years) with meningiomas (n = 16), metastases (n = 12), or gliomas (n = 23) were enrolled. All the patients received 3D APTw imaging scans on a 3.0 T scanner with acceleration by CS (AFs: CS2, CS3, CS4, and CS5) and SENSE (AF: S1.6). Two readers independently and subjectively evaluated the APTw images relative to image quality and measured confidence concerning image blur, distortion, motion, and ghosting artifacts, lesion recognition, and contour delineation with a 5-point Likert scale. Mean amide proton transfer (APT) values of brain tumors (APT _tumor ), the contralateral normal-appearing white matter (APT _CNAWM ), and the peritumoral edema area (if present, APT _edema ) and the tumor volume (V _APT ) were measured for objective evaluation and determination of the optimal AF. The Ki67 labeling index was also measured by using standard immunohistochemical staining procedures in samples from patients with gliomas, and the correlation between tumor APT values and the Ki67 index was analyzed.

Results: The image quality of AF = CS5 was significantly lower than that of other groups. V _APT showed significant differences among the six sequences in meningiomas (p = 0.048) and gliomas (p = 0.023). The pairwise comparison showed that the V _APT values of meningiomas measured from images by CS5 were significantly lower, and gliomas were significantly larger than those by SENSE1.6 and other CS accelerations, (p < 0.05). APT _tumor (p = 0.191) showed no significant difference among the three types of tumors. The APT _tumor values of gliomas measured by APTw images with the SENSE factor of 1.6 and the CS factor of 2, 3, and 4 (except for CS5) were all positively correlated with Ki67.

Conclusion: Compressed SENSE could be successfully extended to accelerated 3D APTw imaging of brain tumors without compromising image quality using the AF of 4.

Keywords: acceleration factor; amide proton transfer; brain tumor; compressed SENSE; peritumoral edema.