Differential expression of the Tmem132 family genes in the developing mouse nervous system

Gene Expr Patterns. 2022 Sep:45:119257. doi: 10.1016/j.gep.2022.119257. Epub 2022 Jun 8.

Abstract

The family of novel transmembrane proteins (TMEM) 132 have been associated with multiple neurological disorders and cancers in humans, but have hardly been studied in vivo. Here we report the expression patterns of the five Tmem132 genes (a, b, c, d and e) in developing mouse nervous system with RNA in situ hybridization in wholemount embryos and tissue sections. Our results reveal differential and partially overlapping expression of multiple Tmem132 family members in both the central and peripheral nervous system, suggesting potential partial redundancy among them.

Keywords: Central nervous system; Embryos; Mouse; Peripheral nervous system; Tmem132a; Tmem132b; Tmem132c; Tmem132d; Tmem132e.

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • Humans
  • In Situ Hybridization
  • Membrane Proteins* / genetics
  • Membrane Proteins* / metabolism
  • Mice
  • Nervous System* / embryology

Substances

  • Membrane Proteins
  • TMEM132A protein, mouse
  • Tmem132d protein, mouse