Novel selenium-containing photosensitizers for near-infrared fluorescence imaging-guided photodynamic therapy

Meiyu Jiang; Jiasheng Wu; Weimin Liu; Haohui Ren; Shuai Wang; Pengfei Wang

doi:10.1016/j.jphotobiol.2022.112488

Novel selenium-containing photosensitizers for near-infrared fluorescence imaging-guided photodynamic therapy

J Photochem Photobiol B. 2022 Aug:233:112488. doi: 10.1016/j.jphotobiol.2022.112488. Epub 2022 Jun 2.

Authors

Meiyu Jiang¹, Jiasheng Wu², Weimin Liu¹, Haohui Ren³, Shuai Wang¹, Pengfei Wang⁴

Affiliations

¹ Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, PR China.
² Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: wujs@mail.ipc.ac.cn.
³ Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
⁴ Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: wangpf@mail.ipc.ac.cn.

PMID: 35689930
DOI: 10.1016/j.jphotobiol.2022.112488

Abstract

Benzopyran nitrile dyes cannot be used as qualified photosensitizers due to the low quantum yield of triplet state. The benzopyran derivatives containing selenium instead of oxygen atom based on the heavy atom effect are expected to become potential agents for photodynamic therapy. In this paper, a series of selenium-containing photosensitizers (PS_X) were prepared according to this strategy. PS_X can effectively produce both singlet oxygen and superoxide anions upon laser irradiation. PS_X exhibited the emission wavelength at 500-800 nm and near-infrared (NIR) fluorescence imaging in HeLa cells. Excellent biocompatibility and phototoxicity further indicated that PS_X could be used as efficient photosensitizers for NIR fluorescence imaging and photodynamic therapy.

Keywords: NIR fluorescence imaging; Photodynamic therapy; Photosensitizer; Selenium.

MeSH terms

Benzopyrans
HeLa Cells
Humans
Optical Imaging
Photochemotherapy* / methods
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use
Selenium*

Substances

Benzopyrans
Photosensitizing Agents
Selenium