Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis

Bioorg Med Chem Lett. 2022 Sep 15:72:128843. doi: 10.1016/j.bmcl.2022.128843. Epub 2022 Jun 7.

Abstract

Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the most effective treatments of CF use a dual or triple combination of CFTR correctors and potentiators. In triple therapy, two correctors (C1 and C2) and a potentiator are employed. Herein, we describe the identification and exploration of the SAR of a series of 4-aminopyrrolidine-2-carboxylic acid C2 correctors of CFTR to be used in conjunction with our existing C1 corrector series for the treatment of CF.

Keywords: Cystic Fibrosis (CF); Cystic Fibrosis Transmembrane Conductance Regulator Protein (CFTR).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzodioxoles
  • Cystic Fibrosis Transmembrane Conductance Regulator* / genetics
  • Cystic Fibrosis Transmembrane Conductance Regulator* / metabolism
  • Cystic Fibrosis* / genetics
  • Humans
  • Mutation
  • Proline / analogs & derivatives
  • Structure-Activity Relationship

Substances

  • Benzodioxoles
  • CFTR protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • 4-aminopyrrolidine-2-carboxylic acid
  • Proline