A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client

Yu-Ying Chen; Thomas V O'Halloran

doi:10.1016/j.cell.2022.05.012

A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client

Cell. 2022 Jun 9;185(12):2013-2015. doi: 10.1016/j.cell.2022.05.012.

Authors

Yu-Ying Chen¹, Thomas V O'Halloran²

Affiliations

¹ Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
² Department of Microbiology and Molecular Genetics, Department of Chemistry, and Elemental Health Institute, Michigan State University, East Lansing, MI 48824, USA. Electronic address: ohallor8@msu.edu.

PMID: 35688131
DOI: 10.1016/j.cell.2022.05.012

Abstract

Zinc is an essential element in living organisms, yet little is known about how cells ensure that zinc is allocated to the correct metalloproteins. Papers in Cell and Cell Reports demonstrate that the ZNG1 family of GTPases have metallochaperone functions: they directly transfer zinc to, and thereby activate, methionine aminopeptidases that are crucial for protein modification during or after translation.

Publication types

Comment

MeSH terms

Metalloproteins* / metabolism
Molecular Chaperones / metabolism
Zinc* / metabolism

Substances

Metalloproteins
Molecular Chaperones
Zinc

Abstract

Publication types

MeSH terms

Substances

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