Three residues in the BTB domain promote a good partnership between NuRD and Thpok

Sci Immunol. 2022 Jun 10;7(72):eabq1408. doi: 10.1126/sciimmunol.abq1408. Epub 2022 Jun 10.

Abstract

Among the BTB-ZF transcription factor family, three amino acids in the BTB domain make Thpok unique in repressing cytotoxic lineage-related genes via recruitment of the NuRD chormatin-remodeling complex (see the related Research Article by Gao et al.).

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • BTB-POZ Domain*
  • Gene Expression Regulation
  • Protein Binding
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Transcription Factors