CO2 to Methanol: A Highly Efficient Enzyme Cascade

Io Antonopoulou; Ulrika Rova; Paul Christakopoulos

doi:10.1007/978-1-0716-2269-8_19

CO₂ to Methanol: A Highly Efficient Enzyme Cascade

Methods Mol Biol. 2022:2487:317-344. doi: 10.1007/978-1-0716-2269-8_19.

Authors

Io Antonopoulou¹, Ulrika Rova², Paul Christakopoulos²

Affiliations

¹ Biochemical Process Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, Luleå, Sweden. io.antonopoulou@ltu.se.
² Biochemical Process Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, Luleå, Sweden.

PMID: 35687244
DOI: 10.1007/978-1-0716-2269-8_19

Abstract

Carbon dioxide (CO₂) has been increasingly regarded not only as a greenhouse gas but also as a valuable feedstock for carbon-based chemicals. In particular, biological approaches have drawn attention as models for the production of value-added products, as CO₂ conversion serves many natural processes. Enzymatic CO₂ reduction in vitro is a very promising route to produce fossil free and bio-based fuel alternatives, such as methanol. In this chapter, the advances in constructing competitive multi-enzymatic systems for the reduction of CO₂ to methanol are discussed. Different integrated methods are presented, aiming to address technological challenges, such as the cost effectiveness, need for material regeneration and reuse and improving product yields of the process.

Keywords: Alcohol dehydrogenase; Carbon dioxide; Clean fuel; Cofactor regeneration; Enzyme cascade; Formaldehyde dehydrogenase; Formate dehydrogenase; Methanol; Oxidoreductase; Reduction.

MeSH terms

Carbon Dioxide*
Methanol*

Substances

Carbon Dioxide
Methanol