A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).
Keywords: RNA signature; immunology; pregnancy; transcriptomics; tuberculosis.
© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.