Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study

Clin Infect Dis. 2022 Dec 19;75(12):2239-2242. doi: 10.1093/cid/ciac437.

Abstract

A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).

Keywords: RNA signature; immunology; pregnancy; transcriptomics; tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Area Under Curve
  • Family
  • Female
  • Humans
  • Mycobacterium tuberculosis*
  • Pregnancy
  • Pregnancy Complications, Parasitic*
  • Pregnant Women
  • Tuberculosis* / diagnosis