Long noncoding RNAs (lncRNAs) in human lymphomas

Ali Gholami; Khosro Farhadi; Fatemeh Sayyadipour; Masoud Soleimani; Fakhredin Saba

doi:10.1016/j.gendis.2021.02.001

Long noncoding RNAs (lncRNAs) in human lymphomas

Genes Dis. 2021 Feb 12;9(4):900-914. doi: 10.1016/j.gendis.2021.02.001. eCollection 2022 Jul.

Authors

Ali Gholami¹, Khosro Farhadi¹, Fatemeh Sayyadipour¹, Masoud Soleimani², Fakhredin Saba³

Affiliations

¹ Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran.
² Department of Haematology, Tarbiat Modares University, Tehran 146899-5513, Iran.
³ Department of Medical Laboratory Science, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran.

Abstract

Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.

Keywords: Apoptosis; Long non-coding RNA; Lymphoma; Prognosis; Proliferation.

Publication types

Review