Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort

Jhong-You Li; Jia-In Lee; Cheng-Chang Lu; Yu-De Su; Chao-Tse Chiu; Szu-Chia Chen; Jiun-Hung Geng; Chung-Hwan Chen

doi:10.3390/nu14112206

Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort

Nutrients. 2022 May 26;14(11):2206. doi: 10.3390/nu14112206.

Authors

Jhong-You Li^{1

2

3}, Jia-In Lee⁴, Cheng-Chang Lu^{1

2

5}, Yu-De Su^{1

2}, Chao-Tse Chiu^{1

2}, Szu-Chia Chen^{6

7

8

9}, Jiun-Hung Geng^{9

10

11}, Chung-Hwan Chen^{2

5

12

13

14

15

16

17

18}

Affiliations

¹ Department of Orthopedics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.
² Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
³ Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁴ Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁵ Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁶ Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.
⁷ Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁸ Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁹ Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹⁰ Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.
¹¹ Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹² Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹³ Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹⁴ Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung City 80145, Taiwan.
¹⁵ Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹⁶ Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80420, Taiwan.
¹⁷ Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.
¹⁸ Ph.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.

Abstract

In this paper, we aimed to examine the protective role of hyperuricemia in the prevalence of osteoporosis in a large Asian cohort. A total of 119,037 participants from 29 recruitment centers in Taiwan were enrolled onto our study. Participants with serum uric acid greater than 7.0 mg/dL in men and 6.0 mg/dL in women were classified as the hyperuricemia group whereas the others were the control group. The mean age of all participants was 50; there were 23,114 subjects (19%) with hyperuricemia. Osteoporosis was observed in 8243 (9%) and 1871 (8%) participants in the control and hyperuricemia groups, respectively. After adjusting for confounders, a lower risk of osteoporosis was found in the hyperuricemia group compared with the control group (odds ratio, 0.916; 95% confidence interval, 0.864 to 0.970). A subgroup analysis showed that hyperuricemia was associated with a lower risk of osteoporosis in females, but not in males. Women with serum uric acid greater than 8.0 mg/dL were not associated with a greater risk of osteoporosis. Our study suggests that hyperuricemia decreases the risk of osteoporosis in females, but not in males. The protective role was no longer apparent when the serum uric acid level was greater than 8 mg/dL.

Keywords: epidemiologic study; hyperuricemia; osteoporosis; risk factors.

MeSH terms

Cohort Studies
Female
Humans
Hyperuricemia* / complications
Hyperuricemia* / epidemiology
Male
Odds Ratio
Osteoporosis* / complications
Osteoporosis* / epidemiology
Risk Factors
Uric Acid

Substances

Uric Acid

Grants and funding

This work was partially supported by the Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan and by Kaohsiung Medical University Research Center Grant (KMU-TC109A01-1 and KMUTC111IFSP01).