This study examined the mediating effect of moral obligation and moderating effect of social value orientation on the relationship between empathy and fairness behavior in Chinese teachers. Seven hundred and twenty-six Chinese teachers completed self-reported questionnaires regarding empathy, moral obligation, social value orientation, and fairness behavior. The results revealed that moral obligation mediated the link between empathy and teachers' fairness behavior. Teachers' social value orientation moderated the associations between empathy and moral obligation and moral obligation and fairness behavior. The associations between empathy and moral obligation and moral obligation and fairness behavior were more robust for those with high SVO scores (i.e., prosocial). This study identified the critical factors associated with teachers' fairness behavior, supplying empirical support for existing theories and providing practical implications for interventions designed to improve Chinese teachers' classroom environment.