Plasma flow chemistry for direct N-acylation of amines by esters

Chem Commun (Camb). 2022 Jun 28;58(52):7281-7284. doi: 10.1039/d2cc01940j.

Authors

Elias Abedelnour^{1

2}, Stephanie Ognier¹, Mengxue Zhang¹, Laurent Schio², Olivier Venier², Janine Cossy³, Michael Tatoulian¹

Affiliations

¹ Chimie Paristech, PSL University, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 - Paris, France. michael.tatoulian@chimieparistech.psl.eu.
² Sanofi, Integrated Drug Discovery - IDD France, 1 Avenue Pierre Brossolette - Chilly Mazarin, France.
³ Molecular, Macromolecular Chemistry and Materials (C3M), ESPCI Paris, PSL University, CNRS, 75005 - Paris, France. janine.cossy@espci.fr.

PMID: 35678143
DOI: 10.1039/d2cc01940j

Abstract

The direct N-acylation of amines by esters in a microreactor is described using argon plasma, thereby producing amides in good to excellent yields.

MeSH terms

Acylation
Amides
Amines*
Esters*

Substances

Amides
Amines
Esters