The results of 77 blood cultures for Brucella in a period of 22 months in Domodossola Hospital (North Italy) are reviewed. Positive results were obtained in 54,80% of cases within the sixth day of incubation. Then of fifteen cultures from apyrectical patients were positive, like then of fifteen in patients with low and not significative titles of agglutinating antibodies. It is concluded for the usefulness of blood culture in every suspicious case of Brucella infection.