When LDL Cholesterol Is Not LDL Cholesterol: LpX, A Clinical Lesson

Lisa P M Huygen; Jan Westerink; Gerben C Mol; Remy H H Bemelmans

doi:10.1016/j.jaccas.2022.03.009

When LDL Cholesterol Is Not LDL Cholesterol: LpX, A Clinical Lesson

JACC Case Rep. 2022 Jun 1;4(11):690-693. doi: 10.1016/j.jaccas.2022.03.009.

Authors

Lisa P M Huygen¹, Jan Westerink², Gerben C Mol³, Remy H H Bemelmans¹

Affiliations

¹ Department of Internal Medicine, Gelderse Vallei Hospital, Ede, the Netherlands.
² Department of Vascular Medicine, University Medical Centre Utrecht, Utrecht, the Netherlands.
³ Department of Internal Medicine, Meander Medical Centre, Amersfoort, the Netherlands.

Abstract

LpX is a lipoprotein formed in cholestatic conditions and often erroneously reported as LDL-C. A low ApoB level can support the diagnosis of LpX. Treatment should not automatically focus on lowering serum lipid levels, but primarily on resolving the cause of cholestasis. (Level of Difficulty: Advanced.).

Keywords: ApoB, apolipoprotein B; HDL, high-density lipoprotein; HDL-C, high-density lipoprotein cholesterol; LDL, low-density lipoprotein; LDL-C, low-density lipoprotein cholesterol; LpX, lipoprotein X; TC, total cholesterol; VLDL, very-low-density lipoprotein; apolipoprotein B; cholestasis; hypercholesterolemia; lipoprotein X.

Publication types

Case Reports