Data on mammary gland microRNAs expression, their predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components

Diana Wu; Amel Taibi; Zhen Lin; Lilian U Thompson; Elena M Comelli

doi:10.1016/j.dib.2022.108328

Data on mammary gland microRNAs expression, their predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components

Data Brief. 2022 May 29:42:108328. doi: 10.1016/j.dib.2022.108328. eCollection 2022 Jun.

Authors

Diana Wu¹, Amel Taibi¹, Zhen Lin¹, Lilian U Thompson¹, Elena M Comelli^{1

2}

Affiliations

¹ Department of Nutritional Sciences, University of Toronto, ON, Canada.
² Joannah and Brian Lawson Centre for Child Nutrition, University of Toronto, ON, Canada.

Abstract

Dietary flaxseed may act via microRNAs (miRNAs) to affect the health of the mammary gland. These data are in support of the article entitled "Effects of flaxseed and its components on mammary gland miRNome: identification of potential biomarkers to prevent breast cancer development" [1]. Here, we provide miRNA expression data obtained from NanoString nCounter® profiling of mammary gland RNA from C57BL/6 female mice who received a control diet or isocaloric diets containing 10% FS, 3.67% FSO, or 0.15% SDG for 21 days. The raw miRNA data were deposited at the NCBI Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193847) under the accession number GSE193847. We also identified diet-associated miRNA-gene targets and corresponding enriched pathways. These data can be found at the HARVARD Dataverse (https://doi.org/10.7910/DVN/3ZNYES). These data will be valuable as a reference to understand the effects of FS versus its components and to study responses to these ingredients in hosts of different genetic backgrounds, sex and age. These data will contribute to future investigations regarding mechanisms underlying FS effects within the mammary gland.

Keywords: Flaxseed; Flaxseed oil; NanoString; female mice; mammary gland; microRNA; secoisolariciresinol diglucoside; target predictions.