Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Ning Wang; Yutong Ma; Huixin Shi; Yiping Song; Shu Guo; Shude Yang

doi:10.3389/fbioe.2022.888084

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Front Bioeng Biotechnol. 2022 May 23:10:888084. doi: 10.3389/fbioe.2022.888084. eCollection 2022.

Authors

Ning Wang¹, Yutong Ma², Huixin Shi¹, Yiping Song¹, Shu Guo¹, Shude Yang^{1

3}

Affiliations

¹ Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China.
² Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China.
³ Liaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology and Department of Oral Pathology, School of Stomatology, China Medical University, Shenyang, China.

Abstract

Implant-associated infection (IAI) is one of the major challenges in orthopedic surgery. The development of implants with inherent antibacterial properties is an effective strategy to resolve this issue. In recent years, biodegradable alloy materials have received considerable attention because of their superior comprehensive performance in the field of orthopedic implants. Studies on biodegradable alloy orthopedic implants with antibacterial properties have gradually increased. This review summarizes the recent advances in biodegradable magnesium- (Mg-), iron- (Fe-), and zinc- (Zn-) based alloys with antibacterial properties as orthopedic implant materials. The antibacterial mechanisms of these alloy materials are also outlined, thus providing more basis and insights on the design and application of biodegradable alloys with antibacterial properties as orthopedic implants.

Keywords: antibacterial; degradable alloys; iron-based alloys; magnesium-based alloys; orthopedic implants; zinc-based alloys.

Publication types

Review