MIR4435-2HG: A Tumor-associated Long Non-coding RNA

Fangnan Zhao; Yuling Liu; Fangshun Tan; Lu Tang; Zhuoying Du; Jie Mou; Gang Zhou; Chengfu Yuan

doi:10.2174/1381612828666220607100228

MIR4435-2HG: A Tumor-associated Long Non-coding RNA

Curr Pharm Des. 2022;28(25):2043-2051. doi: 10.2174/1381612828666220607100228.

Authors

Fangnan Zhao^{1

2}, Yuling Liu^{1

2}, Fangshun Tan^{1

2}, Lu Tang^{1

2}, Zhuoying Du^{1

2}, Jie Mou^{1

2}, Gang Zhou^{3

4}, Chengfu Yuan^{1

2

5}

Affiliations

¹ Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
² Medical College, China Three Gorges University, Yichang 443002, China.
³ College of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
⁴ Yichang Hospital of Traditional Chinese Medicine, Yichang, 443002, China.
⁵ Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China.

PMID: 35674305
DOI: 10.2174/1381612828666220607100228

Abstract

Background: It is well known that the changes in the expression level of LncRNA can affect the progression of tumors, which has caused a great upsurge of research in recent years. Several LncRNAs have been identified to affect a series of cancers and can promote tumor growth, migration, and invasion. In this review, we aim to clarify the pathophysiological functions of LncRNA MIR4435-2 HG in multiple tumors.

Methods: By searching the literature through PubMed, this paper summarizes the relationship between MIR4435-2HG and tumor and its role in the occurrence and development of cancer and also explains the specific molecular mechanism of the effect of MIR4435-2HG on cancer.

Results: MIR4435-2HG can function as an oncogene in a variety of cancers. The expression level was reported to be abnormally elevated in a series of cancers, consisting of melanoma, gastric cancer, head and neck squamous cell carcinoma, oral squamous cell carcinoma, lung cancer, cervical cancer, prostate carcinoma, ovarian cancer, breast cancer, hepatocellular carcinoma, clear cell renal cell carcinoma malignant, glioma, and colorectal cancer. Moreover, MIR4435-2HG is related to the poor prognosis of a variety of cancers. MIR4435-2HG can also affect tumor proliferation, invasion, and apoptosis. In addition, MIR4435-2HG can also enhance the metabolic function of myeloid dendritic cells of elite HIV-1 controllers.

Conclusion: MIR4435-2HG affects the development of a variety of cancers. It can act as a clinical marker for early tumor diagnosis and affects tumor-targeted therapy.

Keywords: LncRNA; MIR4435-2HG; biomarkers; diagnosis; therapeutic target; tumor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Squamous Cell* / genetics
Gene Expression Regulation, Neoplastic
Glioma*
Humans
Liver Neoplasms* / genetics
Male
Mouth Neoplasms* / genetics
RNA, Long Noncoding* / genetics

Substances

MIR4435-2HG long non-coding RNA, human
RNA, Long Noncoding