ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

Romina Royo; Laura Magnano; Julio Delgado; Sara Ruiz-Gil; Josep Ll Gelpí; Holger Heyn; Malcom A Taylor; Tatjana Stankovic; Xose S Puente; Ferran Nadeu; Elías Campo

doi:10.1038/s41408-022-00686-6

ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

Blood Cancer J. 2022 Jun 7;12(6):90. doi: 10.1038/s41408-022-00686-6.

Authors

Romina Royo^#¹, Laura Magnano^#^{2

3

4}, Julio Delgado^{2

3

4

5}, Sara Ruiz-Gil⁶, Josep Ll Gelpí^{1

5}, Holger Heyn^{6

7}, Malcom A Taylor⁸, Tatjana Stankovic⁸, Xose S Puente^{3

9}, Ferran Nadeu^{2

3}, Elías Campo^{10

11

12

13}

Affiliations

¹ Barcelona Supercomputing Center (BSC), Barcelona, Spain.
² Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
⁴ Hospital Clínic of Barcelona, Barcelona, Spain.
⁵ Universitat de Barcelona, Barcelona, Spain.
⁶ CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
⁷ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, UK.
⁹ Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.
¹⁰ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. ecampo@clinic.cat.
¹¹ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. ecampo@clinic.cat.
¹² Hospital Clínic of Barcelona, Barcelona, Spain. ecampo@clinic.cat.
¹³ Universitat de Barcelona, Barcelona, Spain. ecampo@clinic.cat.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Ataxia Telangiectasia Mutated Proteins / genetics
Ataxia Telangiectasia Mutated Proteins / metabolism
Cell Cycle Proteins / genetics
Evolution, Molecular
Germ Cells / metabolism
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Mutation
Young Adult

Substances

Cell Cycle Proteins
ATM protein, human
Ataxia Telangiectasia Mutated Proteins