How human endogenous retroviruses interact with the microbiota in health and disease

Nicholas Dopkins; Morgan M O'Mara; Bhavya Singh; Jez L Marston; Matthew L Bendall; Douglas F Nixon

doi:10.1016/j.tim.2022.05.011

How human endogenous retroviruses interact with the microbiota in health and disease

Trends Microbiol. 2022 Sep;30(9):812-815. doi: 10.1016/j.tim.2022.05.011. Epub 2022 Jun 5.

Authors

Nicholas Dopkins¹, Morgan M O'Mara², Bhavya Singh², Jez L Marston², Matthew L Bendall², Douglas F Nixon²

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: nid4009@med.cornell.edu.
² Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

PMID: 35672223
DOI: 10.1016/j.tim.2022.05.011

Abstract

The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally shape immunity.

Keywords: autoimmunity; endogenous retroviruses; inflammation; microbial dysbiosis; microbiota.

MeSH terms

Dysbiosis
Endogenous Retroviruses* / genetics
Humans
Microbiota*