A step forward for stress-induced ataxia

Hugo G Marques; Pedro L Castelhanito; Megan R Carey

doi:10.1016/j.tins.2022.05.010

A step forward for stress-induced ataxia

Trends Neurosci. 2022 Aug;45(8):566-567. doi: 10.1016/j.tins.2022.05.010. Epub 2022 Jun 4.

Authors

Hugo G Marques¹, Pedro L Castelhanito¹, Megan R Carey²

Affiliations

¹ Neuroscience Program, Champalimaud Center for the Unknown, Lisbon, Portugal.
² Neuroscience Program, Champalimaud Center for the Unknown, Lisbon, Portugal. Electronic address: megan.carey@neuro.fchampalimaud.org.

PMID: 35672171
DOI: 10.1016/j.tins.2022.05.010

Abstract

Patients with episodic ataxia type 2 (EA2) display attacks of severe incoordination and dystonia that can be triggered by stress. In a recent study, Snell, Vitenzon, Tara, and colleagues found a mechanistic pathway by which norepinephrine (NE) alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2 and identified a pharmacological intervention that effectively reduces them.

Keywords: CX-4945; Purkinje cells; ataxia; cerebellum; norepinephrine; stress.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Ataxia* / metabolism
Cerebellum*
Disease Models, Animal
Mice
Mice, Inbred C57BL