Macrophages, masters of invasion

Denise J Montell

doi:10.1016/j.devcel.2022.05.009

Macrophages, masters of invasion

Dev Cell. 2022 Jun 6;57(11):1314-1315. doi: 10.1016/j.devcel.2022.05.009.

Author

Denise J Montell¹

Affiliation

¹ Molecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address: dmontell@ucsb.edu.

Abstract

Macrophages are exceptionally invasive cells. In a recent article in Science, Akhmanova et al. describe a novel mechanism facilitating macrophage infiltration into a tightly packed tissue in Drosophila embryos. Ectodermal cell rounding and division enhance macrophage entry by detaching the dividing cells from the underlying extracellular matrix.

Publication types

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MeSH terms

Animals
Drosophila*
Extracellular Matrix
Macrophages*

Grants and funding

R01 GM046425/GM/NIGMS NIH HHS/United States