Mass spectrometry-based retina proteomics

Mass Spectrom Rev. 2023 May;42(3):1032-1062. doi: 10.1002/mas.21786. Epub 2022 Jun 6.

Abstract

A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry's contributions to facilitate mammalian and avian retina proteomics to catalog and quantify retinal protein expressions, determine their posttranslational modifications, as well as its applications to study the proteome of the retina in the context of biology, health and diseases, and therapy developments.

Keywords: biomarkers; estrogenic retina; photobiology; posttranslational modifications; protein expression; proteomics; retina; retinal diseases; therapeutic targets.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Mammals / metabolism
  • Mass Spectrometry / methods
  • Protein Processing, Post-Translational
  • Proteome* / metabolism
  • Proteomics* / methods
  • Retina / metabolism

Substances

  • Proteome