The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

Yuyan Shen; Xin Huang; Junyun Wu; Xiling Lin; Xiao Zhou; Zhiang Zhu; Xiaowen Pan; Jingya Xu; Jie Qiao; Tianyue Zhang; Linxia Ye; Hongwei Jiang; Yuezhong Ren; Peng-Fei Shan

doi:10.3389/fendo.2022.882241

The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

Front Endocrinol (Lausanne). 2022 May 20:13:882241. doi: 10.3389/fendo.2022.882241. eCollection 2022.

Authors

Yuyan Shen¹, Xin Huang¹, Junyun Wu¹, Xiling Lin¹, Xiao Zhou¹, Zhiang Zhu¹, Xiaowen Pan¹, Jingya Xu¹, Jie Qiao¹, Tianyue Zhang¹, Linxia Ye¹, Hongwei Jiang^{2

3

4}, Yuezhong Ren¹, Peng-Fei Shan^{1

5}

Affiliations

¹ Department of Endocrinology and Metabolism, the Second Affiliated Hospital of ZheJiang University School of Medicine, Hangzhou, China.
² Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
³ Medical Key Laboratory of Hereditary Rare Diseases of Henan, Luoyang, China.
⁴ Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, China.
⁵ Binjing Institute of Zhejiang University, Hangzhou, China.

Abstract

Background: Low bone mineral density (LBMD), including osteoporosis and low bone mass, has becoming a serious public health concern. We aimed to estimate the disease burden of LBMD and its related fractures in 204 countries and territories over the past 30 years.

Methods: We collected detailed information and performed a secondary analysis for LBMD and its related fractures from the Global Burden of Disease Study 2019. Numbers and age-standardized rates related to LBMD of disability-adjusted life-years (DALYs) and deaths in 204 countries and territories were compared by age, gender, socio-demographic index (SDI), and location.

Results: Global deaths and DALYs number attributable to LBMD increased from 207 367 and 8 588 936 in 1990 to 437 884 and 16 647 466 in 2019, with a raise of 111.16% and 93.82%, respectively. DALYs and deaths number of LBMD-related fractures increased 121.07% and 148.65% from 4 436 789 and 121248 in 1990 to 9 808 464 and 301 482 in 2019. In 2019, the five countries with the highest disease burden of DALYs number in LBMD-related fractures were India (2 510 288), China (1 839 375), United States of America (819 445), Japan (323 094), and Germany (297 944), accounting for 25.59%, 18.75%, 8.35%, 3.29%, and 3.04%. There was a quadratic correlation between socio-demographic index (SDI) and burden of LBMD-related fractures: DALYs rate was 179.985-420.435SDI+417.936SDI²(R^{2 =} 0.188, p<0.001); Deaths rate was 7.879-13.416SDI+8.839 SDI²(R^{2 =} 0.101, p<0.001).

Conclusions: The global burden of DALYs and deaths associated with LBMD and its related fractures has increased significantly since 1990. There were differences in disease burden between regions and countries. These estimations could be useful in priority setting, policy-making, and resource allocation in osteoporosis prevention and treatment.

Keywords: death; disability-adjusted life years (DALYs); fracture; global burden; low bone mineral density; osteoporosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

China / epidemiology
Global Burden of Disease*
Global Health
Humans
Osteoporosis* / epidemiology
Quality-Adjusted Life Years