Disrupted Topological Organization of Resting-State Functional Brain Networks in Age-Related Hearing Loss

Wei Yong; Jiajie Song; Chunhua Xing; Jin-Jing Xu; Yuan Xue; Xindao Yin; Yuanqing Wu; Yu-Chen Chen

doi:10.3389/fnagi.2022.907070

Disrupted Topological Organization of Resting-State Functional Brain Networks in Age-Related Hearing Loss

Front Aging Neurosci. 2022 May 20:14:907070. doi: 10.3389/fnagi.2022.907070. eCollection 2022.

Authors

Wei Yong¹, Jiajie Song^{1

2}, Chunhua Xing¹, Jin-Jing Xu³, Yuan Xue⁴, Xindao Yin¹, Yuanqing Wu³, Yu-Chen Chen¹

Affiliations

¹ Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
² Department of Radiology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, China.
³ Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
⁴ Department of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, China.

Abstract

Purpose: Age-related hearing loss (ARHL), associated with the function of speech perception decreases characterized by bilateral sensorineural hearing loss at high frequencies, has become an increasingly critical public health problem. This study aimed to investigate the topological features of the brain functional network and structural dysfunction of the central nervous system in ARHL using graph theory.

Methods: Forty-six patients with ARHL and forty-five age, sex, and education-matched healthy controls were recruited to undergo a resting-state functional magnetic resonance imaging (fMRI) scan in this study. Graph theory was applied to analyze the topological properties of the functional connectomes by studying the local and global organization of neural networks.

Results: Compared with healthy controls, the patient group showed increased local efficiency (E_loc) and clustering coefficient (C_p) of the small-world network. Besides, the degree centrality (Dc) and nodal efficiency (Ne) values of the left inferior occipital gyrus (IOG) in the patient group showed a decrease in contrast with the healthy control group. In addition, the intra-modular interaction of the occipital lobe module and the inter-modular interaction of the parietal occipital module decreased in the patient group, which was positively correlated with Dc and Ne. The intra-modular interaction of the occipital lobe module decreased in the patient group, which was negatively correlated with the E_loc.

Conclusion: Based on fMRI and graph theory, we indicate the aberrant small-world network topology in ARHL and dysfunctional interaction of the occipital lobe and parietal lobe, emphasizing the importance of dysfunctional left IOG. These results suggest that early diagnosis and treatment of patients with ARHL is necessary, which can avoid the transformation of brain topology and decreased brain function.

Keywords: age-related hearing loss; brain function; functional magnetic resonance imaging; graph theory; small-world network.