Local injection of methotrexate ultrasound guided-transvaginal

J Gynecol Obstet Hum Reprod. 2022 Sep;51(7):102419. doi: 10.1016/j.jogoh.2022.102419. Epub 2022 Jun 3.

Abstract

Non-tubal ectopic pregnancies can be located in the uterine portion of the tube (interstitial or cornual), in the cervix (cervical), in a cesarian scar, in the ovary, or intra-abdominally. Even though they are rare, they are associated with a high mortality. Invasive surgeries such as cornuectomy and hysterectomy were common to treat them in case of hemorrhage. Thanks to recent advances in imaging techniques, diagnosis of non-tubal ectopic pregnancy is made earlier and conservative management has been developed in order to respect fertility of patients. Beyond these treatments, systemic or local injection of Methotrexate shows very good success. In the article, we aimed to describe the technics of vaginal injection of in situ methotrexate with ultrasound guidance.

Keywords: Fertility; Methotrexate in situ injection-ultrasound; Non-tubal ectopic pregnancy; Surgery; Vaginal.

MeSH terms

  • Abortifacient Agents, Nonsteroidal*
  • Cicatrix
  • Female
  • Humans
  • Methotrexate
  • Pregnancy
  • Pregnancy, Ectopic*
  • Ultrasonography, Interventional

Substances

  • Abortifacient Agents, Nonsteroidal
  • Methotrexate