Integration of metabolomics and lipidomics reveals serum biomarkers for systemic lupus erythematosus with different organs involvement

Wenqian Zhang; Hongjun Zhao; Pei Du; Haobo Cui; Shuang Lu; Zhongyuan Xiang; Qianjin Lu; Sujie Jia; Ming Zhao

doi:10.1016/j.clim.2022.109057

Integration of metabolomics and lipidomics reveals serum biomarkers for systemic lupus erythematosus with different organs involvement

Clin Immunol. 2022 Aug:241:109057. doi: 10.1016/j.clim.2022.109057. Epub 2022 Jun 3.

Authors

Wenqian Zhang¹, Hongjun Zhao², Pei Du³, Haobo Cui¹, Shuang Lu³, Zhongyuan Xiang⁴, Qianjin Lu⁵, Sujie Jia⁶, Ming Zhao⁷

Affiliations

¹ Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
² Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China.
³ Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha 410011, China.
⁴ Department of Clinical Laboratory, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
⁵ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China.
⁶ Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha 410013, China. Electronic address: sujiejia@csu.edu.cn.
⁷ Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Research Unit of Key Technologies of Diagnosis and Treatment for Immune-related Skin Diseases, Chinese Academy of Medical Sciences, Changsha 410011, China. Electronic address: zhaoming307@csu.edu.cn.

PMID: 35667550
DOI: 10.1016/j.clim.2022.109057

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects various organs or systems. We performed metabolomic and lipidomic profiles analyses of 133 SLE patients and 30 HCs. Differential metabolites and lipids were integrated, and then the biomarker panel was identified using binary logistic regression. We found that a combination of four metabolites or lipids could distinguish SLE from HC with an AUC of 0.998. Three lipids were combined to differentiate inactive SLE and active SLE. The AUC was 0.767. In addition, we also identified the biomarkers for different organ phenotypes of SLE. The AUCs for diagnosing SLE patients with only kidney involvement, skin involvement, blood system involvement, and multisystem involvement were 0.766, 0.718, 0.951, and 0.909, respectively. Our study succeeded in identifying biomarkers associated with different clinical phenotypes in SLE patients, which could facilitate a more precise diagnosis and assessment of disease progression in SLE.

Keywords: Biomarkers; Lipidomics; Metabolomics; SLE.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Humans
Lipidomics*
Lipids
Lupus Erythematosus, Systemic* / genetics
Metabolomics

Substances

Biomarkers
Lipids