Self assembled three dimensional β-Cu2V2O7 hierarchical flower decorated porous carbon: An efficient electrocatalyst for flutamide detection in biological and environmental samples

Sivakumar Musuvadhi Babulal; Jeyaraman Anupriya; Shen Ming Chen

doi:10.1016/j.chemosphere.2022.135203

Self assembled three dimensional β-Cu₂V₂O₇ hierarchical flower decorated porous carbon: An efficient electrocatalyst for flutamide detection in biological and environmental samples

Chemosphere. 2022 Sep;303(Pt 3):135203. doi: 10.1016/j.chemosphere.2022.135203. Epub 2022 Jun 3.

Authors

Sivakumar Musuvadhi Babulal¹, Jeyaraman Anupriya¹, Shen Ming Chen²

Affiliations

¹ Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC.
² Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC. Electronic address: smchen78@ms15.hinet.net.

PMID: 35667499
DOI: 10.1016/j.chemosphere.2022.135203

Abstract

The serious situation mandates the use of anticancer drugs, which protect people all over the world from the growth of prostate cancer. In particular, excessive dosage and erroneous discharge of flutamide concentration cause make environmental pollution on the surface of the wastewater. In this study, the highly sensitive and selective electrochemical approach based on copper vanadium oxide decorated porous carbon (denoted as β-Cu₂V₂O₇/PC) composite modified glassy carbon electrode (GCE) has been developed and it was applied for sensitive detection of anticancer drug flutamide (FTM). Moreover, using the co-precipitation method, the flower-like β-Cu₂V₂O₇ hierarchical microstructure was synthesized, and through the wet chemical process, the β-Cu₂V₂O₇/PC composite was obtained. The resultant product was characterized by XRD, FTIR, RAMAN, XPS and structural morphology established by FESEM analysis. Besides that, the electrochemical characterization and properties were analyzed by cyclic voltammetry (CV) and amperometric (i-t) techniques. The β-Cu₂V₂O₇/PC/RDGCE had two linear ranges at 0.01-2.11 μM and 2.31-30.81 μM. The lower limits of detection and sensitivity were found at 0.62 nM (S/N = 3), and 24.33 μA μM^-1 cm^-2 respectively. The practicability test was applied for the determination of FTM in urine, blood serum and environmental aquatic fluid with satisfactory recovery obtained.

Keywords: Anticancer drug FTM; Electrochemical sensor; Porous carbon; β-Cu(2)V(2)O(7) hierarchical microstructure.

MeSH terms

Carbon* / chemistry
Electrochemical Techniques / methods
Electrodes
Flutamide*
Humans
Limit of Detection
Porosity

Substances

Carbon
Flutamide