A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine

Chemistry. 2022 Aug 26;28(48):e202200906. doi: 10.1002/chem.202200906. Epub 2022 Jul 4.

Abstract

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.

Keywords: RNA therapeutics; lipids; reductive amination; vaccines.

MeSH terms

  • Amination
  • Amino Alcohols
  • COVID-19 Vaccines*
  • COVID-19* / prevention & control
  • Decanoates
  • Humans
  • Lipids
  • Oxidation-Reduction
  • Vaccines, Synthetic
  • mRNA Vaccines

Substances

  • Amino Alcohols
  • COVID-19 Vaccines
  • Decanoates
  • Lipids
  • Vaccines, Synthetic
  • mRNA Vaccines
  • (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)

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