Emphysematous Pyelonephritis Complicated With Hyperglycemic Hyperosmolar State and Sepsis: A Case Report and Literature Review

Cureus. 2022 May 30;14(5):e25498. doi: 10.7759/cureus.25498. eCollection 2022 May.

Abstract

Emphysematous pyelonephritis (EPN) is an acute life-threatening necrotizing infection of the renal parenchyma and perirenal tissues. There are multiple treatment strategies for EPN depending on the initial classification; over the last three decades, the treatment approach has favored kidney sparing strategies and the use of nephrectomy only as salvage therapy. We report a case involving a patient with unilateral emphysematous pyelonephritis complicated with hyperglycemic hyperosmolar state (HHS), sepsis, and multiple risk factors associated with poor prognosis who was successfully treated with conservative management sparing nephrectomy. This case report aims to create awareness among clinicians that even in the presence of multiple risk factors for poor prognosis, conservative management should be considered before nephrectomy.

Keywords: emphysematous pyelonephritis; hyperglycemic hyperosmolar nonketotic state; hyperglycemic hyperosmolar state; hyperglycemic hyperosmolar syndrome; sepsis; shock.

Publication types

  • Case Reports