Miniaturized solid-phase microextraction coupled with gas chromatography-mass spectrometry for determination of endocrine disruptors in drinking water

Mereke Alimzhanova; Madina Mamedova; Kazhybek Ashimuly; Alham Alipuly; Yerlan Adilbekov

doi:10.1016/j.fochx.2022.100345

Miniaturized solid-phase microextraction coupled with gas chromatography-mass spectrometry for determination of endocrine disruptors in drinking water

Food Chem X. 2022 May 23:14:100345. doi: 10.1016/j.fochx.2022.100345. eCollection 2022 Jun 30.

Authors

Mereke Alimzhanova^{1

2}, Madina Mamedova^{1

2}, Kazhybek Ashimuly², Alham Alipuly², Yerlan Adilbekov²

Affiliations

¹ al-Farabi Kazakh National University, Faculty of Physics and Technology, 71 al-Farabi Ave., 050040 Almaty, Kazakhstan.
² Center of Physical Chemical Methods of Research and Analysis, al-Farabi Kazakh National University, 050012 Almaty, Kazakhstan.

Abstract

A simple and rapid method based on miniaturized solid-phase microextraction (mini-SPME) followed by gas chromatography-mass spectrometry was developed to identify eight endocrine disruptors (atrazine, diethylstilbestrol, hexestrol, estrone, estradiol, ethinylestradiol, norgestrel, and megestrel) in drinking water samples. Extraction parameters was optimized and further analyses was performed using them. The optimum temperature for the determination of endocrine disruptors in water was 80 °C; the optimum extraction and preincubation times were 60 and 20 min, respectively. The studied linear range of endocrine disruptors was 10.0-1000 μg mL^-1. The limit of detection ranged from 0.020 to 0.087 μg mL^-1. The correlation coefficient (r²) was 0.96-0.99. This research introduces a novel method for detecting analytes at extremely low concentrations, as well as the possibility of combining several detection technologies to give high-accuracy qualitative and quantitative determination of endocrine disruptors in aqueous samples.

Keywords: Endocrine disruptors; Hormone; Miniaturized SPME; Pesticide; Water.