Brain Function and Upper Limb Deficit in Stroke With Motor Execution and Imagery: A Cross-Sectional Functional Magnetic Resonance Imaging Study

Zhen-Zhen Ma; Jia-Jia Wu; Xu-Yun Hua; Mou-Xiong Zheng; Xiang-Xin Xing; Jie Ma; Si-Si Li; Chun-Lei Shan; Jian-Guang Xu

doi:10.3389/fnins.2022.806406

Brain Function and Upper Limb Deficit in Stroke With Motor Execution and Imagery: A Cross-Sectional Functional Magnetic Resonance Imaging Study

Front Neurosci. 2022 May 19:16:806406. doi: 10.3389/fnins.2022.806406. eCollection 2022.

Authors

Zhen-Zhen Ma¹, Jia-Jia Wu², Xu-Yun Hua^{3

4}, Mou-Xiong Zheng^{3

4}, Xiang-Xin Xing², Jie Ma^{2

4}, Si-Si Li^{2

4}, Chun-Lei Shan^{2

4}, Jian-Guang Xu^{2

4}

Affiliations

¹ Department of Rehabilitation Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Department of Trauma and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁴ School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Background: Motor imagery training might be helpful in stroke rehabilitation. This study explored if a specific modulation of movement-related regions is related to motor imagery (MI) ability.

Methods: Twenty-three patients with subcortical stroke and 21 age-matched controls were recruited. They were subjectively screened using the Kinesthetic and Visual Imagery Questionnaire (KVIQ). They then underwent functional magnetic resonance imaging (fMRI) while performing three repetitions of different motor tasks (motor execution and MI). Two separate runs were acquired [motor execution tasks (ME and rest) and motor imagery (MI and rest)] in a block design. For the different tasks, analyses of cerebral activation and the correlation of motor/imagery task-related activity and KVIQ scores were performed.

Results: During unaffected hand (UH) active grasp movement, we observed decreased activations in the contralateral precentral gyrus (PreCG), contralateral postcentral gyrus (PoCG) [p < 0.05, family wise error (FWE) corrected] and a positive correlation with the ability of FMA-UE (PreCG: r = 0.46, p = 0.028; PoCG: r = 0.44, p = 0.040). During active grasp of the affected hand (AH), decreased activation in the contralateral PoCG was observed (p < 0.05, FWE corrected). MI of the UH induced significant activations of the contralateral superior frontal gyrus, opercular region of the inferior frontal gyrus, and ipsilateral ACC and deactivation in the ipsilateral supplementary motor area (p < 0.05, AlphaSim correction). Ipsilateral anterior cingulate cortex (ACC) activity negatively correlated with MI ability (r = =-0.49, p = 0.022). Moreover, we found significant activation of the contralesional middle frontal gyrus (MFG) during MI of the AH.

Conclusion: Our results proved the dominant effects of MI dysfunction that exist in stroke during the processing of motor execution. In the motor execution task, the enhancement of the contralateral PreCG and PoCG contributed to reversing the motor dysfunction, while in the MI task, inhibition of the contralateral ACC can increase the impaired KVIQ ability. The bimodal balance recovery model can explain our results well. Recognizing neural mechanisms is critical to helping us formulate precise strategies when intervening with electrical or magnetic stimulation.

Keywords: KVIQ; fMRI; motor execution; motor imagery; stroke.