Animal Model Contributions to Primary Congenital Glaucoma

Qiongrong Xia; Dingding Zhang; Yue Zhuang; Yuqian Dai; Haiping Jia; Qiu Du; Taishen Wen; Yuanyuan Jiang

doi:10.1155/2022/6955461

Animal Model Contributions to Primary Congenital Glaucoma

J Ophthalmol. 2022 May 26:2022:6955461. doi: 10.1155/2022/6955461. eCollection 2022.

Authors

Qiongrong Xia¹, Dingding Zhang^{1

2}, Yue Zhuang³, Yuqian Dai⁴, Haiping Jia⁵, Qiu Du¹, Taishen Wen², Yuanyuan Jiang²

Affiliations

¹ Primary Congenital Glaucoma Research Group, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Sichuan Provincial Key Laboratory for Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁴ School of Medicine, St. George's University, New York, USA.
⁵ Department of Immunology, North Sichuan Medical College, Nanchong, China.

Abstract

Primary congenital glaucoma (PCG) is an ocular disease characterized by congenital anterior segmental maldevelopment with progressive optic nerve degeneration. Certain genes, such as cytochrome P450 family 1 subfamily B member 1 and latent TGF-β-binding protein 2, are involved in the pathogenesis of PCG, but the exact pathogenic mechanism has not yet been fully elucidated. There is an urgent need to determine the etiology and pathophysiology of PCG and develop new therapeutic methods to stop disease progression. Animal models can simulate PCG and are essential to study the pathogenesis and treatment of PCG. Various animal species have been used in the study of PCG, including rabbits, rats, mice, cats, zebrafish, and quails. These models are formed spontaneously or by combining with genetic engineering technology. The focus of the present study is to review the characteristics and potential applications of animal models in PCG and provide new approaches to understand the mechanism and develop new treatment strategies for patients with PCG.

Publication types

Review