Interstitial inflammation and pulmonary fibrosis in COVID-19: The potential role of cytostatic therapy for severe lung injury

Elena V Filimonova; Lyubov A Davydova; Mariana A Lysenko; Sergey V Tsarenko

doi:10.1016/j.rmcr.2022.101676

Interstitial inflammation and pulmonary fibrosis in COVID-19: The potential role of cytostatic therapy for severe lung injury

Respir Med Case Rep. 2022:38:101676. doi: 10.1016/j.rmcr.2022.101676. Epub 2022 May 27.

Authors

Elena V Filimonova^{1

2}, Lyubov A Davydova^{1

2

3}, Mariana A Lysenko^{1

4

5}, Sergey V Tsarenko^{1

2

6

3}

Affiliations

¹ State Budgetary Healthcare Institution "Moscow City Clinical Hospital № 52 of Moscow Healthcare Department" (MCCH52), 3 Pekhotnaya Street, Moscow, 123182, Russia.
² Lomonosov Moscow State University, Faculty of Medicine, 27/10 Lomonosovsky Prospekt, Moscow, 119991, Russia.
³ Department of Anesthesiology and Reanimatology at Lomonosov Moscow State University, Faculty of Medicine, 27/10 Lomonosovsky Prospekt, Moscow, 119991, Russia.
⁴ Chief Medical Officer of City Clinical Hospital No. 52 of Moscow Healthcare Department, 3 Pekhotnaya Street, Moscow, 123182, Russia.
⁵ Department of Internal Medicine, Faculty of Additional Professional Education at Federal State Autonomous Educational Institution of Higher Education Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997, Moscow, Russia.
⁶ Deputy Chief Medical Officer in Anesthesiology and Intensive Care at City Clinical Hospital No. 52 of Moscow Healthcare Department, 3 Pekhotnaya Street, 123182, Moscow, Russia.

Abstract

The progression of secondary pulmonary damage in SARS-COV-2 infection, associated with interstitial damage, inflammation and alveolar consolidation and eventually resulted in the development of pulmonary fibrosis (PF), remains one of the key clinical dilemmas for the treatment of patients in intensive care units (ICU). Currently, there is no standardized algorithm for PF prevention and timely management, although few studies have discussed the use of antifibrotic agents in COVID-19 patients. One of the treatment options for patients with interstitial PF, when irresponsive to the given corticosteroid therapy, is the administration of cytostatic agents, in particular, cyclophosphamide. Cyclophosphamide is one of the well-studied drugs in the cytostatic group, which effectiveness in inhibiting systemic inflammation suggests its ability to reduce the progression of the secondary lung damage, interstitial abnormalities and PF caused by the so-called "cytokine storm". The presented case reports provide data on the use of cyclophosphamide (Сy) in the management of severe respiratory failure in COVID-19 patients stationed in ICU. We describe three clinical cases characterized by different types of respiratory support, including extracorporeal membrane oxygenation.

Keywords: COVID-19; Cyclophosphamide; Cytokine storm; Extracorporeal membrane oxygenation; Pulmonary fibrosis; Respiratory failure.

Publication types

Case Reports