Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

María Angeles Vaz Salgado; Julie Earl; Victor Rodriguez Berrocal; Freddy Salge Arrieta; Ana Gomez; Juan Manuel Sepulveda-Sanchez; Ángel Perez-Nuñez; Elena Corral de la Fuente; Daniel Lourido; María Villamayor; Hector Pian; Alfonso Muriel; Elisabetta Rossi; Rita Zamarchi; Alfredo Carrato; Luis Ley

doi:10.2144/fsoa-2022-0008

Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

Future Sci OA. 2022 May 24;8(5):FSO796. doi: 10.2144/fsoa-2022-0008. eCollection 2022 Mar.

Authors

María Angeles Vaz Salgado¹, Julie Earl¹, Victor Rodriguez Berrocal², Freddy Salge Arrieta², Ana Gomez¹, Juan Manuel Sepulveda-Sanchez³, Ángel Perez-Nuñez⁴, Elena Corral de la Fuente¹, Daniel Lourido⁵, María Villamayor¹, Hector Pian⁶, Alfonso Muriel⁷, Elisabetta Rossi^{8

9}, Rita Zamarchi⁹, Alfredo Carrato¹, Luis Ley²

Affiliations

¹ Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain.
² Neurosurgery Department. Ramón y Cajal Hospital, Madrid, 28034, Spain.
³ Medical Oncology Department. 12 de Octubre Hospital. Instituto de Investigación I+12, Madrid, 28041, Spain.
⁴ Neurosurgery Department. 12 de Octubre Hospital, Madrid, 28034, Spain.
⁵ Radiology Department. Ramón y Cajal Hospital, Madrid, 28034, Spain.
⁶ Pathology Department, Ramón y Cajal Hospital, Madrid, 28034, Spain.
⁷ Clinical Biostatistic Unit, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERESP, Nursing Department Universidad de Alcalá Madrid, 28034, Spain.
⁸ Department of Surgery, Oncology & Gastroenterology, University of Padova, Padua, 35124, Italy.
⁹ Veneto Institute of Oncology IOV - IRCCS, Padua, 35128, Italy.

Abstract

Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis.

Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system.

Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM.

Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.

Keywords: biomarker; circulating endothelial cells (CECs); glioblastoma; perfusion MRI.