Bioinspired core-shell silica nanoparticles monitoring extra- and intra-cellular drug release

Tengjisi; Yun Liu; Da Zou; Guangze Yang; Chun-Xia Zhao

doi:10.1016/j.jcis.2022.05.099

Bioinspired core-shell silica nanoparticles monitoring extra- and intra-cellular drug release

J Colloid Interface Sci. 2022 Oct 15:624:242-250. doi: 10.1016/j.jcis.2022.05.099. Epub 2022 May 18.

Authors

Tengjisi¹, Yun Liu², Da Zou¹, Guangze Yang³, Chun-Xia Zhao⁴

Affiliations

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.
² School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, Australia.
³ School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, Australia. Electronic address: guangze.yang@adelaide.edu.au.
⁴ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia; School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, Australia. Electronic address: chunxia.zhao@adelaide.edu.au.

PMID: 35660893
DOI: 10.1016/j.jcis.2022.05.099

Abstract

Förster resonance energy transfer (FRET) has been widely used for monitoring drug release from nanoparticles (NPs). To understand the drug release from bioinspired drug-core silica-shell NPs, we synthesised two types of NPs using the dual-functional peptide SurSi via biosilicification for the first time, i.e., silica NP conjugated with FRET (Cy3 and Cy5) molecules, and FRET-core (DiO and DiI) silica-shell NP with different shell thicknesses (18 and 41 nm). The release kinetics of these two types of NPs were investigated under different conditions, including fetal bovine serum (FBS) and in cells, to mimic the drug release during blood circulation and intracellularly. Two different drug release mechanisms were identified. Cargo diffusion dominated the release during circulation, while the degradation of silica shell played a key role in drug release intracellularly.

MeSH terms

Diffusion
Drug Liberation
Fluorescence Resonance Energy Transfer
Nanoparticles* / chemistry
Silicon Dioxide* / chemistry

Substances

Silicon Dioxide