Miniproteins in medicinal chemistry

Agnieszka Ciesiołkiewicz; Juan Lizandra Perez; Łukasz Berlicki

doi:10.1016/j.bmcl.2022.128806

Miniproteins in medicinal chemistry

Bioorg Med Chem Lett. 2022 Sep 1:71:128806. doi: 10.1016/j.bmcl.2022.128806. Epub 2022 Jun 1.

Authors

Agnieszka Ciesiołkiewicz¹, Juan Lizandra Perez¹, Łukasz Berlicki²

Affiliations

¹ Department of Bioorganic Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
² Department of Bioorganic Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. Electronic address: lukasz.berlicki@pwr.edu.pl.

PMID: 35660515
DOI: 10.1016/j.bmcl.2022.128806

Abstract

Miniproteins exhibit great potential as scaffolds for drug candidates because of their well-defined structure and good synthetic availability. Because of recently described methodologies for their de novo design, the field of miniproteins is emerging and can provide molecules that effectively bind to problematic targets, i.e., those that have been previously considered to be undruggable. This review describes methodologies for the development of miniprotein scaffolds and for the construction of biologically active miniproteins.

Keywords: De novo design; Drug design; Knottins; Peptides; Protein–protein interactions.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Pharmaceutical*
Protein Engineering* / methods