Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis

J Jeya Vandana; Lauretta A Lacko; Shuibing Chen

doi:10.1016/j.stem.2022.05.002

Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis

Cell Stem Cell. 2022 Jun 2;29(6):873-875. doi: 10.1016/j.stem.2022.05.002.

Authors

J Jeya Vandana¹, Lauretta A Lacko², Shuibing Chen³

Affiliations

¹ Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY, NY 10065, USA.
³ Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY, NY 10065, USA. Electronic address: shc2034@med.cornell.edu.

PMID: 35659872
DOI: 10.1016/j.stem.2022.05.002

Abstract

Using an automatic microfluidics droplet platform, Ding et al. successfully replicated the tumor micro-environment by generating micro-organospheres, which were then used to predict the response to anti-tumor drugs. These miniature models could be obtained within an extremely short time frame of 14 days, amplifying their role in facilitating cancer treatment decisions.

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MeSH terms

Humans
Microfluidics
Neoplasms* / diagnosis
Precision Medicine
Tumor Microenvironment