Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells

Mohammad Al-Amin; Nagla Mustafa Eltayeb; Chowdhury Faiz Hossain; Siti Sarah Fazalul Rahiman; Melati Khairuddean; Salizawati Muhamad Salhimi

doi:10.1080/10286020.2022.2081562

Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells

J Asian Nat Prod Res. 2022 Jun 4:1-12. doi: 10.1080/10286020.2022.2081562. Online ahead of print.

Authors

Mohammad Al-Amin¹, Nagla Mustafa Eltayeb^{1

2}, Chowdhury Faiz Hossain³, Siti Sarah Fazalul Rahiman¹, Melati Khairuddean⁴, Salizawati Muhamad Salhimi¹

Affiliations

¹ School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, 11800 USM, Malaysia.
² Tropical Medicine Research Institute (TMRI), National Centre for Research (NCR), 11111 Khartoum, Sudan.
³ Department of Pharmacy, East West University, Jahurul Islam City, Plot no-A/2, Aftabnagar, Dhaka-1212, Bangladesh.
⁴ School of Chemical Sciences, Universiti Sains Malaysia, Pulau Pinang, 11800 USM, Malaysia.

PMID: 35658750
DOI: 10.1080/10286020.2022.2081562

Abstract

Bioassay-guided separation afforded furanodienone 1,10-epoxide (9) as the new compound, curcolone (10) as partially described compound and ten known compounds; germacrone (1), furanodienone (2), curzerenone (3), curcumenol (4), zederone (5), comosone II (6), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (7), 13-hydroxygermacrone (8), curcuzederone (11) and demethoxycurcumin (12). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of C. aeruginosa rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of C. aeruginosa rhizomes.

Keywords: Curcuma aeruginosa rhizomes; Zingiberaceae; cell migration and invasion; comosone II; matrix metalloproteinases; triple-negative breast cancer cells MDA-MB-231.