Progress of exosome research in systemic lupus erythematosus

Jie Shen; Mengyu Zhang; Meiyu Peng

doi:10.1016/j.cytox.2022.100066

Progress of exosome research in systemic lupus erythematosus

Cytokine X. 2022 May 21;4(2-3):100066. doi: 10.1016/j.cytox.2022.100066. eCollection 2022 Jun.

Authors

Jie Shen¹, Mengyu Zhang¹, Meiyu Peng^{1

2}

Affiliations

¹ Weifang Medical University, Weifang 261053, China.
² Department of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, China.

Abstract

Systemic lupus erythematosus (SLE) is a global chronic autoimmune disease that invades most organs of the body, with kidney injury being the most prominent feature. Exosomes are extracellular vesicles that carry a variety of proteins, lipids and genetic material, participate in the exchange of local and intersystem information, and play an important immunoregulatory role in a variety of autoimmune diseases. At the same time, the use of exosomes as disease biomarkers and drug delivery carriers also shows great application prospects. This article reviews current progress in the application of exosomes in the pathogenesis, diagnosis and treatment of SLE.

Keywords: CfDNA, Circulating free DNA; Diagnostic role; Exosomes; HMGB1, High mobility group box 1; Immunomodulation; LN, Lupus nephritis; MSC, Mesenchymal stem cells (MSC); MiRNAs, Microribonucleic acids; Microribonucleic acid; PAMPs, Pathogen-associated molecular patterns; PDCs, Plasmacytoid dendritic cells; SLE, Systemic lupus erythematosus; Systemic lupus erythematosus; TLR, Recombinant Toll Like Receptor; Therapeutic potential; Treg, Regulatory T cells.

Publication types

Review