New Sesquiterpenoids From Plant-Associated Irpex lacteus

Huai-Zhi Luo; Huan Jiang; Xi-Shan Huang; Ai-Qun Jia

doi:10.3389/fchem.2022.905108

New Sesquiterpenoids From Plant-Associated Irpex lacteus

Front Chem. 2022 May 17:10:905108. doi: 10.3389/fchem.2022.905108. eCollection 2022.

Authors

Huai-Zhi Luo^{1

2}, Huan Jiang², Xi-Shan Huang³, Ai-Qun Jia¹

Affiliations

¹ School of Pharmaceutical Sciences, Key Laboratory of Tropical Biological Resources of Ministry of Education, One Health Institute, Hainan University, Haikou, China.
² School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
³ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, China.

Abstract

Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, irpexolaceus H (1) and I (2), along with two known furan compounds, irpexlacte B (3) and C (4), were isolated from Orychophragmus violaceus (L.) OE Schulz endophytic fungus Irpex lacteus (Fr.) Fr. Their structures were elucidated by detailed spectroscopic data (NMR, HRESIMS, IR, and UV), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analysis. Furthermore, those compounds were evaluated for anti-quorum sensing (anti-QS) activity, and compound 3 was found contributing to the potential QS inhibitory activity.

Keywords: Irpex lacteus (Fr.) Fr; Orychophragmus violaceus (L.) O.E. Schulz; furan; quorum sensing; sesquiterpenoids.