1H, 13C and 15N resonance assignments of TbBDF5-bromo1 domain from Trypanosoma brucei

Li Yang; Xiaole Zhang; Jiahai Zhang; Xiaoming Tu

doi:10.1007/s12104-022-10088-1

¹H, ¹³C and ¹⁵N resonance assignments of TbBDF5-bromo1 domain from Trypanosoma brucei

Biomol NMR Assign. 2022 Oct;16(2):253-255. doi: 10.1007/s12104-022-10088-1. Epub 2022 Jun 2.

Authors

Li Yang¹, Xiaole Zhang¹, Jiahai Zhang², Xiaoming Tu³

Affiliations

¹ MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.
² MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China. zhangjh@ustc.edu.cn.
³ MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China. xmtu@ustc.edu.cn.

PMID: 35652998
DOI: 10.1007/s12104-022-10088-1

Abstract

¹H, ¹³C and ¹⁵N resonance assignments are presented for the first bromo domain of TbBDF5 (TbBDF5-bromo1) from Trypanosoma brucei. TbBDF5 is localized in the nucleus and plays a potential role in transcription regulation. Bromo domains can recognize acetylated histone through a conserved binding pocket. Here we report the NMR resonance assignments of TbBDF5-bromo1 domain for further studies of the relationship between its structure and function.

Keywords: Bromo domain; Resonance assignment; TbBDF5; Trypanosoma brucei.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Histones / chemistry
Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Protozoan Proteins / chemistry
Trypanosoma brucei brucei* / metabolism

Substances

Histones
Protozoan Proteins