Antibacterial activity of guanidinium-based ionic covalent organic framework anchoring Ag nanoparticles

Hongxu Zhang; Jing Ma; Chong Liu; Ling Li; Caina Xu; Yanwei Li; Yanhui Li; Huayu Tian

doi:10.1016/j.jhazmat.2022.128965

Antibacterial activity of guanidinium-based ionic covalent organic framework anchoring Ag nanoparticles

J Hazard Mater. 2022 Aug 5:435:128965. doi: 10.1016/j.jhazmat.2022.128965. Epub 2022 Apr 20.

Authors

Hongxu Zhang¹, Jing Ma¹, Chong Liu¹, Ling Li¹, Caina Xu², Yanwei Li³, Yanhui Li⁴, Huayu Tian⁵

Affiliations

¹ School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Department of Biochemistry, School of Basic Medical Sciences, Jilin University, Changchun 130021, PR China.
³ School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, PR China. Electronic address: liyanwei@cust.edu.cn.
⁴ School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: lyh2008@cust.edu.cn.
⁵ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Science and Technology of China, Hefei 230026, PR China.

PMID: 35650719
DOI: 10.1016/j.jhazmat.2022.128965

Abstract

In this paper, the antibacterial 2D covalent organic framework (COF_TGTp) containing guanidyl cation was synthesized and used as a carrier to deposit AgNPs on N and O groups to form nanocomposites to avoid AgNPs aggregation and achieve excellent antibacterial effect. The Ag content in Ag/COF_TGTp was 10.3% determined by ICP. TEM can clearly observe that AgNPs were uniformly dispersed in COF_TGTp. Ag/COF_TGTp was stable after being evenly dispersed in water with low cytotoxicity and hemolysis rate to erythrocytes. In bacteriostatic study, the minimum inhibitory concentration of Ag/COF_TGTp for E. coli and S. aureus were 100 μg/mL and 50 μg/mL, respectively. Finally, the morphology of the bacteria was observed by SEM, confirmed the main sterilization by Ag/COF_TGTp was destroying the cell wall of the bacteria.

Keywords: Antibacterial; Antibiotic resistance; Broad-spectrum; Covalent organic framework; Silver nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Escherichia coli
Guanidine / pharmacology
Ions
Metal Nanoparticles* / toxicity
Metal-Organic Frameworks* / pharmacology
Silver / pharmacology
Staphylococcus aureus

Substances

Anti-Bacterial Agents
Ions
Metal-Organic Frameworks
Silver
Guanidine