WNK1 kinase signaling in metastasis and angiogenesis

Chia-Ying Hou; Chung-Yung Ma; Chiou-Hwa Yuh

doi:10.1016/j.cellsig.2022.110371

WNK1 kinase signaling in metastasis and angiogenesis

Cell Signal. 2022 Aug:96:110371. doi: 10.1016/j.cellsig.2022.110371. Epub 2022 May 29.

Authors

Chia-Ying Hou¹, Chung-Yung Ma², Chiou-Hwa Yuh³

Affiliations

¹ Institute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
² Institute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan.
³ Institute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; Ph.D. Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: chyuh@nhri.org.tw.

PMID: 35649473
DOI: 10.1016/j.cellsig.2022.110371

Abstract

With-no-lysine kinases (WNKs) are a novel family of serine/threonine protein kinases participating in ion homeostasis via the WNK-OSR1/SPAK-NKCC cascade. Recent studies of WNK1 have revealed that its related signaling pathways mediated tumor-induced angiogenesis and carcinogenesis and uncovered novel roles of WNK1 in endothelial cell migration and proliferation, tumor cell proliferation, and metastasis. Herein, we review the functions of WNK1 in cancer metastasis and angiogenesis and propose WNK1 targeting as an anti-cancer strategy.

Keywords: Angiogenesis; Ion homeostasis; Metastasis; Signaling pathways; WNK-OSR1/SPAK-NKCC.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Intracellular Signaling Peptides and Proteins* / metabolism
Minor Histocompatibility Antigens
Protein Serine-Threonine Kinases*
Signal Transduction / physiology
WNK Lysine-Deficient Protein Kinase 1 / metabolism

Substances

Intracellular Signaling Peptides and Proteins
Minor Histocompatibility Antigens
Protein Serine-Threonine Kinases
WNK Lysine-Deficient Protein Kinase 1