Enhanced Mechanical Strength, Flexibility, and Shape-Restoring Rate of a Drug-Eluting Shape-Memory Polymer by Incorporation of Supramolecular Cross-Linkers

Jiae Seo; Jae-Won Choi; Young-Hag Koh; Ji-Hun Seo

doi:10.1021/acsmacrolett.9b00996

Enhanced Mechanical Strength, Flexibility, and Shape-Restoring Rate of a Drug-Eluting Shape-Memory Polymer by Incorporation of Supramolecular Cross-Linkers

ACS Macro Lett. 2020 Mar 17;9(3):389-395. doi: 10.1021/acsmacrolett.9b00996. Epub 2020 Feb 27.

Authors

Jiae Seo¹, Jae-Won Choi², Young-Hag Koh², Ji-Hun Seo¹

Affiliations

¹ Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea.
² Department of Biomedical Engineering, Korea University, Seoul 02841, Korea.

PMID: 35648540
DOI: 10.1021/acsmacrolett.9b00996

Abstract

The purpose of this study is to develop mechanically robust soybean oil and polycaprolactone (PC)-based drug-eluting shape memory polymers (SMPs) containing polyrotaxane (PRX) cross-linkers. Essentially, the dynamic PRX cross-linker-containing methacrylate group is introduced to increase the cross-linking density and flexibility of the SMP to overcome its mechanical limitations. It was confirmed that the elongation and cross-linking density of the PRX-incorporated SMP were increased by 2-4 times compared to neat SMP. In addition, those high mechanical properties of the PRX-incorporated SMP could be maintained after the degradation of the PC by the drug-eluting process.