Prognostic Significance of PD-L1 Expression and Standardized Uptake Values in the Primary Lesions of Stage IV Adenocarcinoma Lung Cancer

Bui Tien Cong; Pham Cam Phuong; Pham-Van Thai; Vu-Le Thuong; Nguyen Quang Hung; Dong-Thi Hang; Hoang Anh Tuan; Doan Minh Khuy; Pham-Van Tuyen; Nguyen Minh Duc

doi:10.3389/fmed.2022.895401

Prognostic Significance of PD-L1 Expression and Standardized Uptake Values in the Primary Lesions of Stage IV Adenocarcinoma Lung Cancer

Front Med (Lausanne). 2022 May 13:9:895401. doi: 10.3389/fmed.2022.895401. eCollection 2022.

Authors

Bui Tien Cong^{1

2}, Pham Cam Phuong^{1

2}, Pham-Van Thai^{1

2}, Vu-Le Thuong^{1

2}, Nguyen Quang Hung², Dong-Thi Hang³, Hoang Anh Tuan⁴, Doan Minh Khuy⁴, Pham-Van Tuyen⁴, Nguyen Minh Duc⁵

Affiliations

¹ Department of Nuclear Medicine, Ha Noi Medical University, Hanoi, Vietnam.
² Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
³ Department of Examination, Bach Mai Hospital, Hanoi, Vietnam.
⁴ Pathology and Cytology Center, Bach Mai Hospital, Hanoi, Vietnam.
⁵ Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

Abstract

Background: This study evaluated the prognostic ability of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) in patients with stage IV adenocarcinoma lung cancer to detect protein death-ligand 1 (PD-L1) expression levels.

Methods: In total, 86 patients with stage IV adenocarcinoma lung cancer underwent ¹⁸F-FDG PET/CT imaging and PD-L1 expression evaluation before treatment from February 2019 to November 2020 at Bach Mai Hospital, Hanoi, Vietnam. The assessed patient characteristics in this study included sex, age, smoking status, epidermal growth factor receptor (EGFR) mutation, PD-L1 expression level, survival status, tumor, node, and metastasis (TNM) stage, and metastasis locations.

Results: The average age was 62.23 ± 9.51 years, and men and women represented 67.4% and 32.6% of the population, respectively. The EGFR mutation rate was 36%. PD-L1 expression was negative (detected in <1% of the tumor) in 40.7% of cases and positive in 59.3% of cases (detected in 1-49% of the tumor in 32.6%; detected in ≥50% of the tumor in 26.7%). The mean maximum standardized uptake value (SUV_max) was 11.09 ± 3.94. SUV_max was significantly higher in PD-L1-positive tumors than in PD-L1-negative tumors (12.24 ± 4.01 and 9.43 ± 3.22, respectively; p = 0.001). Receiver operating characteristic curve analysis revealed an area under the curve of SUVmax was 0.681 (95% confidence interval 0.570-0.793, p = 0.004). Compared with PD-L1-negative cases, SUV_max was significantly different in all PD-L1-positive cases (p = 0.001), weakly PD-L1-positive cases (1-49%, p = 0.005), and strongly PD-L1-positive cases (≥50%, p = 0.003). PD-L1 expression levels were significantly associated with SUV_max (p = 0.001), tumor size (p = 0.022), and EGFR mutation status (p = 0.045).

Conclusions: SUV_max in the primary lesions was able to predict PD-L1 expression and may play a role in predicting PD-L1 immunotherapy efficacy in patients with stage IV lung adenocarcinoma.

Keywords: FDG PET/CT; PD-L1; SUVmax; adenocarcinoma; lung cancer; prediction; stage IV.