Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Xiangyu Lin; Liang Zhu; Jing He

doi:10.3389/fcell.2022.899095

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Front Cell Dev Biol. 2022 May 12:10:899095. doi: 10.3389/fcell.2022.899095. eCollection 2022.

Authors

Xiangyu Lin¹, Liang Zhu¹, Jing He¹

Affiliation

¹ Department of Pathology and Pathophysiology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic growth characteristics. The hair growth cycle is divided into three continuous stages, growth (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen). And The Morphogenesis and cycle of hair follicles are regulated by a variety of signal pathways. When the signal molecules in the pathways are abnormal, it will affect the development and cycle of hair follicles, which will lead to hair follicle-related diseases.This article will review the structure, development, cycle and molecular regulation of hair follicles, in order to provide new ideas for solving diseases and forming functional hair follicle.

Keywords: BMP; WNT; hair cycling; hair follicles; morphogenesis.

Publication types

Review