Red Blood Cell Distribution Width to Platelet Count Ratio Facilitates Preoperative Prediction of Recurrence in Surgically Treated Chronic Subdural Hematoma

Ági Güresir; Christoph Coch; Annkristin Heine; Elvira Mass; Tim Lampmann; Hartmut Vatter; Markus Velten; Marie-Therese Schmitz; Erdem Güresir; Johannes Wach

doi:10.3389/fneur.2022.884231

Red Blood Cell Distribution Width to Platelet Count Ratio Facilitates Preoperative Prediction of Recurrence in Surgically Treated Chronic Subdural Hematoma

Front Neurol. 2022 May 11:13:884231. doi: 10.3389/fneur.2022.884231. eCollection 2022.

Authors

Affiliations

¹ Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.
² Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
³ Department of Internal Medicine III for Hematology, Oncology, Rhemuatology and Immune-Oncology, University Hospital Bonn, Bonn, Germany.
⁴ Life and Medical Sciences Institute (LIMES), Developmental Biology of the Immune System, University of Bonn, Bonn, Germany.
⁵ Department of Anesthesiology and Critical Care Medicine, University Hospital Bonn, Bonn, Germany.
⁶ Department of Medical Biometry, Informatics and Epidemiology, Medical Faculty Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.

Abstract

Objective: Recent studies have demonstrated emerging evidence of the role of inflammation in the growth and recurrence of chronic subdural hematoma (cSDH). Red blood cell distribution width to platelet count ratio (RPR) is a novel biomarker for inflammation in cancer, cardiac, and inflammatory diseases. The present retrospective study investigated the impact of RPR on recurrence after burr hole surgery for cSDH in 297 patients.

Methods: The optimal cut-off value for RPR was defined as ≥0.0568 according to the receiver operating characteristic curve (AUC:0.64, 95%CI:0.55-0.72, p = 0.007). The study cohort was dichotomized into low (n = 157) and high (n = 140) RPR groups.

Results: Significant differences between the groups were identified regarding American Society of Anesthesiologists (ASA) classification and frequency of anticoagulant intake. Demographics, comorbidities, size, morphology, and mass effect of cSDH were homogeneously distributed among the RPR groups. Multivariable binary logistic regression analysis considering location, midline-shift, septation, RPR, anticoagulant intake, sex, and ASA classification revealed that an increased baseline RPR (≥0.0568, OR: 3.1, 95%CI: 1.4-6.8, p = 0.004), and preoperative midline-shift (≥5 mm, OR: 2.7, 95%CI: 1.3-6.0, p = 0.01) are independent predictors of recurrent cSDH.

Conclusion: The present findings suggest RPR as a novel inflammatory biomarker enabling risk stratification of recurrence after burr hole surgery for cSDH and might facilitate tailored medical decision making.

Keywords: chronic subdural hematoma; inflammation; platelet count; recurrence; red blood cell distribution width.